Enzymatically Triggered Actuation of Miniaturized Tools

Enzymatically triggered rupture of polymersomes.

Polymersomes are robust vesicles made from amphiphilic block co-polymers. Large populations of uniform giant polymersomes with defined, entrapped species can be made by templating of double-emulsions using microfluidics. In the present study, a series of two enzymatic reactions, one inside and the other outside of the polymersome, were designed to induce rupture of polymersomes. We measured how...

Enzymatically triggered self-assembly of block copolymers.

The polymerization of vinyl monomers with cleavable enzymatic substrates has been shown to lead to water-soluble double-hydrophilic block copolymers which, upon enzymatic activation of the diblock copolymers, become amphiphilic and undergo self-assembly into colloidal nanostructures. The ability to change the chemical and physical characteristics of polymeric materials by an enzymatic reaction ...

Towards Miniaturized Diagnostic Tools

Self - Triggered Control : trading actuation for computation . ∗

Event-triggered and self-triggered control have recently been proposed as alternatives to the well established periodic implementation of control loops on digital platforms. In a self-triggered implementation, the control task is responsible for computing the new actuator values as well as the next instant of time at which the state should be sampled, the control law recomputed, and the actuato...

Self-assembled prodrugs: an enzymatically triggered drug-delivery platform.

Enzyme catalysis as a tool to disassemble supramolecular hydrogels to control the release of encapsulated drugs provides an opportunity to design a wide range of enzyme-specific low-molecular-weight hydrogelators. In this proof-of-concept work, we report the synthesis of low-molecular-weight amphiphilic prodrugs as hydrogelators from a well-known drug acetaminophen (which belongs to a class of ...